Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2.
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Aksoy IA, Callen DF, Apostolou S, Her C, Weinshilboum RM
Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2.
Genomics. 1994 Sep 1;23(1):275-7.
- PubMed ID
- 7829089 [ View in PubMed]
- Abstract
Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.