Antinociception induced by central administration of histamine in the formalin test in rats.

Article Details

Citation

Copy to clipboard

Mojtahedin A, Tamaddonfard E, Zanboori A

Antinociception induced by central administration of histamine in the formalin test in rats.

Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54.

PubMed ID

19552055 [ View in PubMed

]

Abstract

In the present study, effects of intracerebroventricular (icv) administration of histamine, mepyramine (H1-receptor antagonist) and famotidine (H2-receptor antagonist) have been investigated on the formalin test in rats. Subcutaneous injection of formalin (50 microl, 1%) into the ventral surface of the left hind paw produced a marked biphasic pain response (first phase: 0-5 min and second phase: 15-45 min). All the performed treatments did not significantly influence the first phase of pain. Histamine at the doses of 10 and 40 microg and mepyramine and famotidine at the same doses of 20 and 80 microg, significantly (P < 0.05) decreased the late phase of formalin-induced pain. Pretreatments with mepyramine and famotidine at the same dose of 80 microg, significantly (P < 0.05) prevented the histamine (40 microg)-induced antinociception. These results indicate that brain histamine produces antinociception, and both central H1 and H2 receptors may involve in the histamine-induced antinociception in the formalin test in rats.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Mepyramine	Histamine H1 receptor	Protein	Humans	Yes	Antagonist	Details