Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

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Citation

Sutcliffe JG

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

Proc Natl Acad Sci U S A. 1978 Aug;75(8):3737-41.

PubMed ID
358200 [ View in PubMed
]
Abstract

I have determined the nucleotide sequence of the ampicillin resistance gene of pBR322, an Escherichia coli plasmid that encodes a penicillin beta-lactamase. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the mature enzyme, whose partial amino acid sequence has been determined independently.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Beta-lactamase TEMP62593Details