C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation.
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Lopez-Goyanes A, Moreno MA, Ferre S, Paz-Artal E
C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation.
Tissue Antigens. 2004 Mar;63(3):260-2.
- PubMed ID
- 14989716 [ View in PubMed]
- Abstract
The present work reports the DNA sequence of the polymorphic region from the uncommon complement allele C4B93. It shows a new combination of Chido and Rodgers antigenicities and expresses reverse antigenicity because it carries Rodgers 1, 2, and 3. C4B93 could have arisen from an ancient, non-homologous recombination between C4A3 (or C4A6) and C4B1a or from a homologous recombination between C4B1a and C4B5. These events would be enhanced by the presence of recombination promoting Escherichia colichi-like signals in the fragment between positions 1157 and 1186. The generation of the C4 polymorphism by recombination would explain the concerted evolution of C4 genes in primates.