Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice.

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Nishio M, Kanda Y, Mizuno K, Watanabe Y

Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice.

Neurosci Lett. 2002 Dec 16;334(3):145-8.

PubMed ID

12453616 [ View in PubMed

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Abstract

This study investigates the involvement of alpha(2)-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha(2A)-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal alpha(2A)-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, alpha(1D)-AR, were not changed by the treatment. Moreover, alpha(o)-subunits of GTP-binding proteins (Galpha(o)), one of the downstream molecules of alpha(2A)-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of alpha(2A)-AR in the mouse hippocampus.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Metamfetamine	Alpha-2A adrenergic receptor	Protein	Humans	Yes	Agonist	Details