First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan.
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Saito R, Takahashi R, Sawabe E, Koyano S, Takahashi Y, Shima M, Ushizawa H, Fujie T, Tosaka N, Kato Y, Moriya K, Tohda S, Tojo N, Koike R, Kubota T
First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan.
Antimicrob Agents Chemother. 2014 May;58(5):2961-3. doi: 10.1128/AAC.02072-13. Epub 2014 Feb 24.
- PubMed ID
- 24566171 [ View in PubMed]
- Abstract
We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene blaKPC-2, which was present on the transferable plasmid of ca. 190 kb, in addition to the blaCTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-blaKPC-2-ISKpn6-like), encompassing blaKPC-2, were found to be similar to those of K. pneumoniae strains from China.