Identification and characterization of functional domains in a mixed lineage kinase LZK.

Article Details

Citation

Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T

Identification and characterization of functional domains in a mixed lineage kinase LZK.

FEBS Lett. 2001 Jan 19;488(3):190-5.

PubMed ID
11163770 [ View in PubMed
]
Abstract

The mixed lineage kinase (MLK) family is a recently described protein kinase family. The MLKs contain a kinase domain followed by a dual leucine zipper-like motif. We previously reported the molecular cloning of LZK (leucine zipper-bearing kinase), a novel MLK, and that LZK activated the c-Jun NH2 terminal kinase (JNK)/stress-activated protein kinase (SAPK) pathway through MKK7 in cells. Here, we reveal that LZK forms dimers/oligomers through its dual leucine zipper-like motif, and that this is necessary for activation of the JNK/SAPK pathway. We also identify the C-terminal functional region of LZK, which is indispensable for the activation of SEK1, but not that of MKK7.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Mitogen-activated protein kinase kinase kinase 13O43283Details