The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.
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Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP
The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.
Biochemistry. 2010 Sep 21;49(37):7972-4. doi: 10.1021/bi100409w.
- PubMed ID
- 20726546 [ View in PubMed]
- Abstract
A complex of RON(M1254T) with AMP-PNP and Mg(2+) reveals a substratelike positioning of Tyr1238 as well as likely catalysis-competent placement of the AMP-PNP and Mg(2+) components and indicates a tendency for cis phosphorylation. The structure shows how the oncogenic mutation may cause the constitutive activation and suggests a mechanistic hypothesis for the autophosphorylation of receptor tyrosine kinases.