Topiramate And Phentermine

Article Details


Johnson DB, Quick J

Topiramate And Phentermine


PubMed ID
29489234 [ View in PubMed

Phentermine and extended-release (ER) topiramate have been used separately in a variety of ways. Phentermine was first introduced in 1959 as part of an anti-obesity combination drug. Topiramate was discovered in 1979 but was not released for commercial use until 1996. Phentermine on its own has been used for short-term treatment of obesity in combination with exercise and caloric restriction. Topiramate on its own has been used to treat partial-onset or primary generalized tonic-clonic seizures, Lennox-Gastaut syndrome, and as a prophylactic treatment of migraine headaches. Non-FDA approved indications for topiramate include: sleep related eating disorder, nightmares - PTSD associated, and alcohol dependence. The United States Food and Drug Administration approved the combination of these 2 drugs in 2012 to treat obesity. The drugs are to be used in combination with a reduced-calorie diet and exercise program in individuals with an initial body mass index (BMI) over 30 kg/m2 or in those with a BMI of over 27 in combination with at least one obesity-related comorbidity.[1][2][3]

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