Drug-induced cholestasis.
Article Details
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Padda MS, Sanchez M, Akhtar AJ, Boyer JL
Drug-induced cholestasis.
Hepatology. 2011 Apr;53(4):1377-87. doi: 10.1002/hep.24229.
- PubMed ID
- 21480339 [ View in PubMed]
- Abstract
Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Erythromycin Bile salt export pump Protein Humans NoSubstrateInhibitorDetails