Drug-induced cholestasis.

Article Details

Citation

Padda MS, Sanchez M, Akhtar AJ, Boyer JL

Drug-induced cholestasis.

Hepatology. 2011 Apr;53(4):1377-87. doi: 10.1002/hep.24229.

PubMed ID
21480339 [ View in PubMed
]
Abstract

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
ErythromycinBile salt export pumpProteinHumans
No
Substrate
Inhibitor
Details