Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy.

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Perazella MA

Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy.

Kidney Int. 2010 Dec;78(11):1060-3. doi: 10.1038/ki.2010.344.

PubMed ID

21076445 [ View in PubMed

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Abstract

Tenofovir, used in combination with other antiretroviral agents, is an effective therapy for HIV infection. Although large clinical studies and post-marketing data support a benign renal profile for tenofovir, numerous cases of kidney injury raise concern for nephrotoxic potential. Early human studies and experimental evidence suggested that tenofovir itself was not associated with mitochondrial toxicity within the kidney. However, recent animal data demonstrate that tenofovir causes mitochondrial DNA depletion and mitochondrial toxicity. Herlitz et al. confirm the nephrotoxicity of tenofovir in humans. They describe its clinical consequences, histopathologic findings, and its mitochondrial toxicity in HIV+ patients.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Tenofovir disoproxil	Canalicular multispecific organic anion transporter 1	Protein	Humans	Unknown	Substrate	Details