5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.

Article Details

Citation

Copy to clipboard

Pithadia AB, Jain SM

5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.

J Clin Med Res. 2009 Jun;1(2):72-80. doi: 10.4021/jocmr2009.05.1237. Epub 2009 Jun 21.

PubMed ID

22505971 [ View in PubMed

]

Abstract

UNLABELLED: 5-hydroxytryptamine (5-HT) has become one of the most investigated and complex biogenic amines. The main receptors and their subtypes, e.g., 5-HTI (5-HT1A, 5-HT1B, 5-HTID, 5-HTIE and 5-HT1F), 5-HT2 (5-HT2A, 5-HT2B and 5-HT2C), 5-HT3, 5-HT4, 5-HT5 (5-HT5A, 5-HT5B), 5-HT6 and 5-HT7 have been identified. Specific drugs which are capable of either selectively stimulating or inhibiting these receptor subtypes are being designed. This has generated therapeutic potentials of 5-HT receptor modulators in a variety of disease conditions. Conditions where 5-HT receptor modulators have established their use with distinct efficacy and advantages include migraine, anxiety, psychosis, obesity and cancer therapy-induced vomiting by cytotoxic drugs and radiation. Discovery of 5-HT, its biosynthesis, metabolism, physiological role and the potential of 5-HT receptor modulators in various nervous, cardiovascular and gastrointestinal tract disorders, bone growth and micturition have been discussed in this article. KEYWORDS: 5-hydroxytryptamine (5-HT) receptors; Modulators; Biogenic amines.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amitriptyline	5-hydroxytryptamine receptor 1C	Protein	Rat	Unknown	Antagonist	Details