5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.

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Lesch KP, Disselkamp-Tietze J, Schmidtke A

5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.

J Neural Transm Gen Sect. 1990;80(2):157-61.

PubMed ID

2317317 [ View in PubMed

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Abstract

Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1A-mediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulated during AMI treatment.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amitriptyline	5-hydroxytryptamine receptor 1A	Protein	Humans	Unknown	Inhibitor Inducer	Details