Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes.
Article Details
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Christians U, Schmidt G, Bader A, Lampen A, Schottmann R, Linck A, Sewing KF
Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes.
Br J Clin Pharmacol. 1996 Mar;41(3):187-90.
- PubMed ID
- 8866917 [ View in PubMed]
- Abstract
1. Tacrolimus, an immunosuppressive macrolide, is metabolized by enzymes of the cytochrome P450 3A subfamily. In this study, 34 drugs were tested for their interactions with tacrolimus metabolism by human liver microsomes. 2. Fifteen drugs which inhibit the in vitro metabolism of tacrolimus were identified: bromocriptine, corticosterone, dexamethasone, ergotamine, erythromycin, ethinyloestradiol, josamycin, ketoconazole, miconazole, midazolam, nifedipine, omeprazole, tamoxifen, troleandomycin and verapamil.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Dexamethasone Cytochrome P450 3A4 Protein Humans UnknownSubstrateInhibitorInducerDetails Dexamethasone acetate Cytochrome P450 3A4 Protein Humans UnknownSubstrateInhibitorInducerDetails Dexamethasone isonicotinate Cytochrome P450 3A4 Protein Humans NoSubstrateInhibitorInducerDetails