Tryptophan catabolism in IDO+ plasmacytoid dendritic cells.

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Fallarino F, Gizzi S, Mosci P, Grohmann U, Puccetti P

Tryptophan catabolism in IDO+ plasmacytoid dendritic cells.

Curr Drug Metab. 2007 Apr;8(3):209-16.

PubMed ID

17430109 [ View in PubMed

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Abstract

Plasmacytoid dendritic cells (pDCs) represent a specialized cell population that produces large amounts of type I interferons, the so-called natural interferon-producing cells. Recently, murine and human pDCs have been credited with a unique ability to express indoleamine 2,3-dioxygenase (IDO) and to mediate immunosuppression in specific settings. This suggests an important role for IDO-expressing pDCs in controlling the balance of inflammation and tolerance. Here we review recent advances in our understanding of how these cells may be critical at the interface of inflammation and tolerance and discuss the potential for therapeutic IDO modulation as an immunoregulatory maneuver targeting pDC function.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Tryptophan	Indoleamine 2,3-dioxygenase 1	Protein	Humans	Unknown	Substrate	Details