Antidepressants and the muscarinic acetylcholine receptor.
Article Details
- CitationCopy to clipboard
Snyder SH, Yamamura HI
Antidepressants and the muscarinic acetylcholine receptor.
Arch Gen Psychiatry. 1977 Feb;34(2):236-9.
- PubMed ID
- 14603 [ View in PubMed]
- Abstract
Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Amitriptyline Muscarinic acetylcholine receptor (Protein Group) Protein group Humans UnknownLigandDetails