Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type.
Article Details
- CitationCopy to clipboard
Lewis AJ, Truman P, Hosking MR, Miller JH
Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type.
Tob Control. 2012 Jan;21(1):39-43. doi: 10.1136/tc.2010.040287. Epub 2011 Jun 2.
- PubMed ID
- 21636610 [ View in PubMed]
- Abstract
BACKGROUND: It has been suggested that inhibition of monoamine oxidase (MAO) activity by components of cigarette smoke may impact on smoking addiction, but it is unclear to what extent the known MAO inhibitors in tobacco smoke cause this inhibition. METHODS: MAO inhibitory activity was measured in a series of tobacco particulate matter preparations from different brands of cigarette and loose-leaf tobacco commonly available in New Zealand. RESULTS: When tobacco extracts were diluted to contain a physiologically relevant nicotine concentration of 0.2 muM, all samples tested inhibited MAO-A and MAO-B by between 4% and 12% in a standard assay. Per mg of nicotine, samples from factory-made cigarettes contained significantly less MAO inhibitory activity than did samples from loose-leaf tobacco. When inhibitory activity was calculated on a per mg of tar basis, there was no significant difference between loose-leaf tobaccos and factory-made cigarettes. CONCLUSIONS: The present study shows that the ratio of nicotine to MAO inhibitory activity varies depending on the type of tobacco product used. The roll-your-own tobaccos tested delivered more tar and more MAO inhibitory activity per mg of nicotine than the factory-made cigarettes. These findings suggest that smokers of roll-your-own tobacco may experience greater difficulty in stopping smoking.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Nicotine Amine oxidase [flavin-containing] A Protein Humans UnknownInhibitorDetails Nicotine Amine oxidase [flavin-containing] B Protein Humans UnknownInhibitorDetails