Acute topiramate overdose--clinical manifestations.

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Wisniewski M, Lukasik-Glebocka M, Anand JS

Acute topiramate overdose--clinical manifestations.

Clin Toxicol (Phila). 2009 Apr;47(4):317-20. doi: 10.1080/15563650601117954.

PubMed ID
19514879 [ View in PubMed
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Abstract

INTRODUCTION: The clinical manifestations of acute topiramate toxicity are described. METHODS: Seven cases of acute and acute-on-chronic topiramate toxicity observed in two clinical units of Polish Poison Control Centers in 2004-2005 were analyzed. RESULTS: The patients were 4 women and 2 men aged between 16 and 38 (mean 21.0 +/- 8.4) years. The doses of topiramate ranged from 10.7 to 218 mg/kg. The most frequent symptom was somnolence (66.7%) and, vertigo, agitation, and mydriasis were less common (33.4%). One patient who was not previously treated with topiramate experienced three secondarily generalized tonic-clonic seizures. Metabolic acidosis, lasting for 3-7 days, was observed in four cases, and did not influence the outcome. CONCLUSIONS: The clinical manifestations of acute poisonings with topiramate ranged from asymptomatic to severe, but no distant sequelae or fatalities were observed. The course of acute poisoning seems to be more severe in patients who were not previously treated with topiramate.

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