Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.

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Gherasim C, Lofgren M, Banerjee R

Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.

J Biol Chem. 2013 May 10;288(19):13186-93. doi: 10.1074/jbc.R113.458810. Epub 2013 Mar 28.

PubMed ID

23539619 [ View in PubMed

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Abstract

The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility, supporting both methyl transfer and isomerization reactions. During evolution of higher eukaryotes that utilize vitamin B12, the high reactivity of the cofactor coupled with its low abundance pressured development of an efficient system for uptake, assimilation, and delivery of the cofactor to client B12-dependent enzymes. Although most proteins suspected to be involved in B12 trafficking were discovered by 2009, the recent identification of a new protein reveals that the quest for elucidating the intracellular B12 highway is still far from complete. Herein, we review the biochemistry of cobalamin trafficking.

DrugBank Data that Cites this Article

Drugs

Cyanocobalamin

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Cyanocobalamin	Pancreatic proteases	Group		Unknown	Substrate	Details

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Cyanocobalamin	Cubilin	Protein	Humans	Unknown	Substrate	Details
Cyanocobalamin	Multidrug resistance-associated protein 1	Protein	Humans	Unknown	Not Available	Details