Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: an overview.

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Flore KM, Delanghe JR

Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: an overview.

Perit Dial Int. 2009 Jul-Aug;29(4):377-83.

PubMed ID

19602602 [ View in PubMed

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Abstract

Current point-of-care testing (POCT) glucometers are based on various test principles. Two major method groups dominate the market: glucose oxidase-based systems and glucose dehydrogenase-based systems using pyrroloquinoline quinone (GDH-PQQ) as a cofactor. The GDH-PQQ-based glucometers are replacing the older glucose oxidase-based systems because of their lower sensitivity for oxygen. On the other hand, the GDH-PQQ test method results in falsely elevated blood glucose levels in peritoneal dialysis patients receiving solutions containing icodextrin (e.g., Extraneal; Baxter, Brussels, Belgium). Icodextrin is metabolized in the systemic circulation into different glucose polymers, but mainly maltose, which interferes with the GDH-PQQ-based method. Clinicians should be aware of this analytical interference. The POCT glucometers based on the GDH-PQQ method should preferably not be used in this high-risk population and POCT glucose results inconsistent with clinical suspicion of hypoglycemic coma should be retested with another testing system.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Icodextrin	Pancreatic alpha-amylase	Protein	Humans	Unknown	Substrate	Details