The biosynthesis of adenosylcobalamin (vitamin B12).

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Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC

The biosynthesis of adenosylcobalamin (vitamin B12).

Nat Prod Rep. 2002 Aug;19(4):390-412.

PubMed ID

12195810 [ View in PubMed

]

Abstract

Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Cyanocobalamin	Bifunctional adenosylcobalamin biosynthesis protein CobU	Protein	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	Unknown	Product of	Details