Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine.

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Citation

Johnson HG, Miller MD

Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine.

Agents Actions. 1979 Aug;9(3):239-43.

PubMed ID
Abstract

We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ChlorpromazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details