Acetylation of 5-aminosalicylate by hamster colon arylamine N-acetyltransferase.
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Tucker MA, Smith TJ
Acetylation of 5-aminosalicylate by hamster colon arylamine N-acetyltransferase.
J Appl Toxicol. 1990 Feb;10(1):73-4.
- PubMed ID
- 2335716 [ View in PubMed]
- Abstract
Recent evidence suggests that 5-aminosalicylate acts as an anti-inflammatory agent by virtue of its ability to act as a free-radical scavenger. The major metabolite, N-acetyl-5-aminosalicylate is not an effective free-radical scavenger. We have demonstrated that an arylamine N-acetyltransferase from hamster colon can directly acetylate 5-aminosalicylate, suggesting that the colon may have the ability to modulate the activity of this agent through metabolic inactivation.