Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.

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Sergerie Y, Boivin G

Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.

Antimicrob Agents Chemother. 2006 Nov;50(11):3889-92. doi: 10.1128/AAC.00889-06. Epub 2006 Sep 18.

PubMed ID
16982796 [ View in PubMed
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Abstract

Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high levels of resistance to ACV.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ValaciclovirThymidine kinaseProteinHHV-1
Yes
Substrate
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