Vitamin E transport, membrane incorporation and cell metabolism: Is alpha-tocopherol in lipid rafts an oar in the lifeboat?

Article Details

Citation

Lemaire-Ewing S, Desrumaux C, Neel D, Lagrost L

Vitamin E transport, membrane incorporation and cell metabolism: Is alpha-tocopherol in lipid rafts an oar in the lifeboat?

Mol Nutr Food Res. 2010 May;54(5):631-40. doi: 10.1002/mnfr.200900445.

PubMed ID
20166147 [ View in PubMed
]
Abstract

Vitamin E is composed of closely related compounds, including tocopherols and tocotrienols. Studies of the last decade provide strong support for a specific role of alpha-tocopherol in cell signalling and the regulation of gene expression. It produces significant effects on inflammation, cell proliferation and apoptosis that are not shared by other vitamin E isomers with similar antioxidant properties. The different behaviours of vitamin E isomers might relate, at least in part, to the specific effects they exert at the plasma membrane. alpha-Tocopherol is not randomly distributed throughout the phospholipid bilayer of biological membranes, and as compared with other isomers, it shows a propensity to associate with lipid rafts. Distinct aspects of vitamin E transport and metabolism is discussed with emphasis on the interaction between alpha-tocopherol and lipid rafts and the consequences of these interactions on cell metabolism.

DrugBank Data that Cites this Article

Drugs
Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
Vitamin EPhospholipid transfer proteinProteinHumans
Unknown
Binder
Details
Vitamin ESEC14-like protein 2ProteinHumans
Unknown
Binder
Details
Vitamin ESEC14-like protein 3ProteinHumans
Unknown
Binder
Details
Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
Vitamin EATP-binding cassette sub-family A member 1ProteinHumans
Unknown
Substrate
Details
Vitamin EScavenger receptor class B member 1ProteinHumans
Unknown
Substrate
Details