Vitamin E transport, membrane incorporation and cell metabolism: Is alpha-tocopherol in lipid rafts an oar in the lifeboat?
Article Details
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Lemaire-Ewing S, Desrumaux C, Neel D, Lagrost L
Vitamin E transport, membrane incorporation and cell metabolism: Is alpha-tocopherol in lipid rafts an oar in the lifeboat?
Mol Nutr Food Res. 2010 May;54(5):631-40. doi: 10.1002/mnfr.200900445.
- PubMed ID
- 20166147 [ View in PubMed]
- Abstract
Vitamin E is composed of closely related compounds, including tocopherols and tocotrienols. Studies of the last decade provide strong support for a specific role of alpha-tocopherol in cell signalling and the regulation of gene expression. It produces significant effects on inflammation, cell proliferation and apoptosis that are not shared by other vitamin E isomers with similar antioxidant properties. The different behaviours of vitamin E isomers might relate, at least in part, to the specific effects they exert at the plasma membrane. alpha-Tocopherol is not randomly distributed throughout the phospholipid bilayer of biological membranes, and as compared with other isomers, it shows a propensity to associate with lipid rafts. Distinct aspects of vitamin E transport and metabolism is discussed with emphasis on the interaction between alpha-tocopherol and lipid rafts and the consequences of these interactions on cell metabolism.
DrugBank Data that Cites this Article
- Drugs
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Vitamin E Phospholipid transfer protein Protein Humans UnknownBinderDetails Vitamin E SEC14-like protein 2 Protein Humans UnknownBinderDetails Vitamin E SEC14-like protein 3 Protein Humans UnknownBinderDetails - Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Vitamin E ATP-binding cassette sub-family A member 1 Protein Humans UnknownSubstrateDetails Vitamin E Scavenger receptor class B member 1 Protein Humans UnknownSubstrateDetails