In vitro anticholinesterase activity of various alkaloids.

Article Details

Citation

Copy to clipboard

Orhan I, Naz Q, Kartal M, Tosun F, Sener B, Choudhary MI

In vitro anticholinesterase activity of various alkaloids.

Z Naturforsch C. 2007 Sep-Oct;62(9-10):684-8.

PubMed ID

18069241 [ View in PubMed

]

Abstract

In the current study, a number of alkaloids including retamine, cytisine, and sparteine (quinolizidine-type), yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type) were tested in vitro for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at 1 mg/ml concentration by the Ellman method using an ELISA microplate reader. Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively]. While the rest of the alkaloids did not show any significant inhibition against AChE, three of the alkaloids, namely retamine, sparteine, and yohimbine, exerted a noteworthy anti-BChE effect as compared to galanthamine, the reference drug.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Capsaicin	Cholinesterase	Protein	Humans	Unknown	Inhibitor	Details