cAMP and mitochondria.

Article Details


Valsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G

cAMP and mitochondria.

Physiology (Bethesda). 2013 May;28(3):199-209. doi: 10.1152/physiol.00004.2013.

PubMed ID
23636265 [ View in PubMed

Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.

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