In vitro actions of some antibiotics on phospholipases.

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Sugatani J, Saito K, Honjo I

In vitro actions of some antibiotics on phospholipases.

J Antibiot (Tokyo). 1979 Jul;32(7):734-9.

PubMed ID

541266 [ View in PubMed

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Abstract

The effects of some antibiotics on activities of phospholipase A2, B and C were investigated in vitro. Tetracyclines, macrolides, chloramphenicol and carbenicillin inhibited the activity of Crotalus adamanteus phospholipase A2 towards phospholipids of egg-yolk emulsions. When the ability to inhibit the activity of Penicillium notatum phospholipase B towards mixed micelles of phosphatidylcholine and Triton X-100 was investigated, polymyxin B was found to be inhibitory while chloramphenicol and carbenicillin were found to stimulate the activity of the phospholipase. The activity of Bacillus cereus phospholipase C towards the mixed micelles was inhibited by bleomycin, oleandomycin and chloramphenicol.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Carbenicillin	Cytosolic phospholipase A2	Protein	Humans	Unknown	Inhibitor	Details