Androgen Physiology, Pharmacology and Abuse
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Androgen Physiology, Pharmacology and Abuse
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- PubMed ID
- 25905231 [ View in PubMed]
- Abstract
Testosterone, together with its bioactive metabolites dihydrotestosterone and estradiol, determines the development and maintenance of male sexual differentiation and the characteristic mature masculine features. Defects in androgen action at various epochs of life produce characteristic clinical features. From an outline of the biochemistry and physiology of androgen action, the pathophysiology of defects in androgen action are derived and defined. The pharmacology of testosterone and its applications to replacement therapy for pathological hypogonadism as well as for pharmacological androgen therapy based on using either testosterone or synthetic androgens is described. For complete coverage of all related areas of Endocrinology, please see our FREE on line web-book, www.endotext.org.
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