Effect of corticotropin-releasing factor on adrenal DBH and PNMT activity.

Article Details

Citation

Lima L, Sourkes TL

Effect of corticotropin-releasing factor on adrenal DBH and PNMT activity.

Peptides. 1987 May-Jun;8(3):437-41.

PubMed ID
3498935 [ View in PubMed
]
Abstract

The continuous administration of CRF (corticotropin-releasing factor) by the intraventricular route, 100 ng/day, to rats over a period of 7 days, results in significant increases of DBH (dopamine beta-hydroxylase) and PNMT (phenethanol N-methyltransferase) activities in the adrenal glands. The pattern of increase in DBH response to various doses of CRF does not correspond to the effects observed on plasma corticosterone, a result that suggests that CRF is acting to increase the adrenal enzyme by means other than through the pituitary-adrenal axis. In contrast, PNMT responds to CRF in a manner indicating a correlation with glucocorticoid availability. Moreover, PNMT induction by CRF persists even after adrenal denervation; it also occurs when CRF is given subcutaneously for 3 days, in a dose of 60 ng/day. Injection of reserpine did not potentiate the effect of intraventricularly administered CRF.

DrugBank Data that Cites this Article

Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
CorticorelinDopamine beta-hydroxylaseProteinHumans
Unknown
Inducer
Details