Abilities of peroxidases to catalyse peroxidase-oxidase oxidation of thiols.

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Svensson BE

Abilities of peroxidases to catalyse peroxidase-oxidase oxidation of thiols.

Biochem J. 1988 Dec 15;256(3):757-62.

PubMed ID

2852004 [ View in PubMed

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Abstract

The abilities of various peroxidases to catalyse the peroxidase-oxidase oxidation of seven aminothiols were studied. Cysteamine and cysteine esters were found to be peroxidase-oxidase substrates for eosinophil peroxidase and myeloperoxidase, whereas other thiols tested were inactive or poorly active with these peroxidases. With lactoperoxidase and horseradish peroxidase, all the tested thiols were inactive or poorly active as peroxidase-oxidase substrates. These studies suggest that a main reason for thiols being poor peroxidase-oxidase substrates is because these thiols are poor peroxidatic substrates.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Cysteamine	Myeloperoxidase	Protein	Humans	Unknown	Substrate	Details