Growth hormone modulates serum cholinesterase.

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Lamartiniere CA

Growth hormone modulates serum cholinesterase.

Endocrinology. 1986 Mar;118(3):1252-4.

PubMed ID

3948777 [ View in PubMed

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Abstract

Adult male rats have lower serum cholinesterase activity levels than adult female rats and hypophysectomized male rats have higher activity levels than sham-operated males (similar to control females). GH administered to hypophysectomized male rats abolishes the effect of hypophysectomy on serum cholinesterase. Adult male rats treated neonatally with monosodium L-glutamate to induce arcuate nucleus lesions of the hypothalamus have higher serum cholinesterase activities and decreased serum GH concentrations. GH administered to these male rats results in decreased serum cholinesterase activities. These experiments demonstrate that GH is a negative modulator of serum cholinesterase in the male rat.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Pegvisomant	Cholinesterase	Protein	Humans	Unknown	Inhibitor	Details