Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer.

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Bhargava S

Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer.

Med Hypotheses. 2014 Apr;82(4):428-32. doi: 10.1016/j.mehy.2014.01.016. Epub 2014 Jan 26.

PubMed ID
24548754 [ View in PubMed
]
Abstract

Androgenic alopecia, a condition characterized by increased levels of DHT could have been selected for due to the benefits that prostaglandin D2 (PGD(2)) has on the prostate. A DHT metabolite can increase the transcription of prostaglandin D2 synthase through estrogen receptor beta. The increase of PGD(2) can decrease the risk of prostate cancer and proliferation of prostate cancer cells. Therefore, the mechanisms behind male pattern baldness may also curtail the advancement of prostate cancer.

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