Cardiac GPCRs: GPCR signaling in healthy and failing hearts.

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Salazar NC, Chen J, Rockman HA

Cardiac GPCRs: GPCR signaling in healthy and failing hearts.

Biochim Biophys Acta. 2007 Apr;1768(4):1006-18. doi: 10.1016/j.bbamem.2007.02.010. Epub 2007 Feb 20.

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17376402 [ View in PubMed
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Abstract

G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.

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