Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes.

Article Details

Citation
Copy to clipboard

Dharnidharka VR, Nadeau K, Cannon CL, Harris HW, Rosen S

Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes.

Am J Kidney Dis. 1998 Apr;31(4):710-2.

PubMed ID
9531191 [ View in PubMed
]
Abstract

Acute renal failure due to ciprofloxacin has been well described. The previously reported cases have been consistent both clinically and pathologically with tubulointerstitial nephritis (TIN). We report a case of ciprofloxacin overdose leading to acute renal failure characterized by acute tubular necrosis (ATN). The outstanding features in the patient's renal biopsy were those of distal nephron apoptosis, best seen in plastic-embedded sections and electron microscopy. This report shows that the distal nephron can be singularly involved in acute renal failure and that electron microscopy or plastic-embedded sections may be necessary to define its involvement.

DrugBank Data that Cites this Article

Drugs