Massive isotretinoin intoxication.

Article Details

Citation

Aubin S, Lorette G, Muller C, Vaillant L

Massive isotretinoin intoxication.

Clin Exp Dermatol. 1995 Jul;20(4):348-50.

PubMed ID
8548998 [ View in PubMed
]
Abstract

We report a case of acute intoxication due to a massive overdose of isotretinoin. A 29-year-old male patient ingested 900 mg of isotretinoin corresponding to 12.5 mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously, We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side-effects were mild and represented only exacerbations of some common isotretinoin side-effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotretinoin overdose.

DrugBank Data that Cites this Article

Drugs