PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics.

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Fohner AE, McDonagh EM, Clancy JP, Whirl Carrillo M, Altman RB, Klein TE

PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics.

Pharmacogenet Genomics. 2017 Jan;27(1):39-42. doi: 10.1097/FPC.0000000000000246.

PubMed ID

27636560 [ View in PubMed

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Abstract

Not Available

DrugBank Data that Cites this Article

Drugs

Ivacaftor

Tezacaftor

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ivacaftor	Cystic fibrosis transmembrane conductance regulator	Protein	Humans	Yes	Potentiator	Details

Drug Reactions

Reaction
Ivacaftor DB08820 Cytochrome P450 3A4 Cytochrome P450 3A5 M1 (hydroxymethyl-ivacaftor) DBMET02318	Details
Ivacaftor DB08820 Cytochrome P450 3A4 Cytochrome P450 3A5 M6 (ivacaftor-carboxylate) DBMET02319	Details