Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer.
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Guimbellot JS, Acosta EP, Rowe SM
Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer.
Pediatr Pulmonol. 2018 May;53(5):E6-E8. doi: 10.1002/ppul.23971. Epub 2018 Feb 28.
- PubMed ID
- 29488691 [ View in PubMed]
- Abstract
The CFTR potentiator ivacaftor is responsible for significant clinical improvements among a subset of patients with cystic fibrosis. Because it is a substrate of the cytochrome P450 system, specifically CYP3A4/5, ivacaftor is subject to significant drug-drug interactions, including due to commonly used antimicrobials such as rifampin. While the interaction of rifampin and ivacaftor has been examined in vitro, severe adverse events resulting from this interaction have not been reported in the literature. In this report, we describe the termination of steady, long-term improvement in a patient taking ivacaftor, resulting from the use of rifampin and precipitating a significant pulmonary exacerbation.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Ivacaftor Cytochrome P450 3A4 Protein Humans NoSubstrateInhibitorDetails Ivacaftor Cytochrome P450 3A5 Protein Humans NoSubstrateInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your software1,2-BenzodiazepineIvacaftor The serum concentration of 1,2-Benzodiazepine can be increased when it is combined with Ivacaftor. AbemaciclibIvacaftor The serum concentration of Abemaciclib can be increased when it is combined with Ivacaftor. AbirateroneIvacaftor The serum concentration of Abiraterone can be increased when it is combined with Ivacaftor. AcalabrutinibIvacaftor The serum concentration of Acalabrutinib can be increased when it is combined with Ivacaftor. AcetaminophenIvacaftor The serum concentration of Acetaminophen can be increased when it is combined with Ivacaftor.