Neuronal Nicotinic Acetylcholine Receptors and Epilepsy.

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Bertrand D

Neuronal Nicotinic Acetylcholine Receptors and Epilepsy.

Epilepsy Curr. 2002 Nov;2(6):191-193. doi: 10.1046/j.1535-7597.2002.00072.x.

PubMed ID
15309115 [ View in PubMed
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Abstract

The identification of a genetically transmissible form of epilepsy that is associated with a mutation in CHRNA4, the gene that encodes the alpha4 subunit of the high-affinity nicotinic acetylcholine receptor, was the first demonstration that an alteration in a ligand-gated ion channel can cause seizures. Since then, nine mutations have been found, and analysis of their physiologic properties has revealed that all of them enhance receptor function.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CarbamazepineNeuronal acetylcholine receptor subunit alpha-4ProteinHumans
Unknown
Not AvailableDetails