Antiarrhythmic effect of bisoprolol, a highly selective beta1-blocker, in patients with paroxysmal atrial fibrillation.

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Ishiguro H, Ikeda T, Abe A, Tsukada T, Mera H, Nakamura K, Yusu S, Yoshino H

Antiarrhythmic effect of bisoprolol, a highly selective beta1-blocker, in patients with paroxysmal atrial fibrillation.

Int Heart J. 2008 May;49(3):281-93.

PubMed ID

18612186 [ View in PubMed

]

Abstract

In the treatment of arrhythmia, beta-blockers are mainly used to regulate the heart rate. However, beta-blockers are also known as drugs with an antiarrhythmic effect due to the suppression of sympathetic activity. We evaluated the antiarrhythmic effects of a highly selective beta(1)-blocker, bisoprolol, in patients with diurnal paroxysmal atrial fibrillation (P-AF). A total of 136 patients with symptomatic diurnal P-AF were enrolled. Patients were divided into a diurnal-specific P-AF group and a diurnal & nocturnal P-AF group, as well as into a bisoprolol single use group and a combined use group with an antiarrhythmic drug. The effects of bisoprolol were evaluated in 3 categories: subjective symptom improvement, quality of life (QOL) improvement, and elimination of P-AF episode in Holter electrocardiograms (ECGs). For patients with effective treatment, a long-term effect up to 24 months was evaluated. Five patients (3.7%) discontinued bisoprolol due to side effects. Following administration of bisoprolol, 109 patients (80%) experienced subjective symptom improvement, 103 patients (76%) experienced QOL improvement, and elimination of P-AF episodes in ECGs was observed in 84 patients (62%). The elimination rate of P-AF episodes in ECGs was higher in the diurnal P-AF group than in the diurnal & nocturnal P-AF group (P=0.042). There was no significant difference between the bisoprolol single use group and the combined use group. A long-term suppressive effect by bisoprolol was observed in 70 of 83 patients (84%). The results demonstrate that bisoprolol has an antiarrhythmic effect against sympathetic diurnal P-AF, improving subjective symptoms and QOL and eliminating P-AF episodes in ECGs.

DrugBank Data that Cites this Article

Drugs

Bisoprolol

Drug Interactions

Drugs	Interaction
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Acetyldigitoxin Bisoprolol	The therapeutic efficacy of Acetyldigitoxin can be increased when used in combination with Bisoprolol.
Adenosine Bisoprolol	The therapeutic efficacy of Adenosine can be increased when used in combination with Bisoprolol.
Ajmaline Bisoprolol	The therapeutic efficacy of Ajmaline can be increased when used in combination with Bisoprolol.
Atropine Bisoprolol	The therapeutic efficacy of Atropine can be increased when used in combination with Bisoprolol.
Bepridil Bisoprolol	The therapeutic efficacy of Bepridil can be increased when used in combination with Bisoprolol.