Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.

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Schwinn DA, Roehrborn CG

Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.

Int J Urol. 2008 Mar;15(3):193-9. doi: 10.1111/j.1442-2042.2007.01956.x.

PubMed ID

18304211 [ View in PubMed

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Abstract

Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). alpha(1)-Adrenoceptors (alpha(1)ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific alpha(1)AR subtypes in the treatment of LUTS.

DrugBank Data that Cites this Article

Drugs

Alfuzosin

Doxazosin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Doxazosin	Alpha-1A adrenergic receptor	Protein	Humans	Yes	Antagonist	Details
Doxazosin	Alpha-1B adrenergic receptor	Protein	Humans	Unknown	Not Available	Details
Doxazosin	Alpha-1D adrenergic receptor	Protein	Humans	Yes	Antagonist	Details