Renal effects of angiotensin II receptor blockade in normotensive subjects.

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Burnier M, Roch-Ramel F, Brunner HR

Renal effects of angiotensin II receptor blockade in normotensive subjects.

Kidney Int. 1996 Jun;49(6):1787-90.

PubMed ID

8743498 [ View in PubMed

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Abstract

Several new non-peptide, orally active, angiotensin II receptor antagonists have recently been developed which enable to block the renin-angiotensin system at the AT1 receptor site. In contrast to angiotensin converting enzyme (ACE) inhibitors, these antagonists do not interfere with the metabolism of kinins. The effect of these agents on renal function may thus potentially differ from those of ACE inhibitors. Therefore, the renal pharmacology of various angiotensin II receptor antagonists has been examined in normotensive subjects. In normotensive subjects, losartan and irbesartan have been shown to have no effect on glomerular filtration rate and to induce either no change or a modest increase in renal blood flow. These results were confirmed thereafter in hypertensive patients where losartan produced a renal vasodilation with no change in glomerular filtration. In healthy subjects, both losartan and irbesartan induce an acute increase in urinary sodium excretion. The natriuretic response to losartan is proportionally more important during salt-depletion. In contrast to other angiotensin II receptor antagonists, losartan has a unique property to increase uric acid excretion. In this paper we show that this property is due to the potent inhibitory effect of the parent compound of losartan on the urate/anion transport in the human renal proximal tubule.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Losartan	Solute carrier family 2, facilitated glucose transporter member 9	Protein	Humans	Unknown	Inhibitor	Details
Losartan	Solute carrier family 22 member 12	Protein	Humans	Unknown	Inhibitor	Details