Cilastatin (MK 0791) is a potent and specific inhibitor of the renal leukotriene D4-dipeptidase.

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Koller M, Brom J, Raulf M, Konig W

Cilastatin (MK 0791) is a potent and specific inhibitor of the renal leukotriene D4-dipeptidase.

Biochem Biophys Res Commun. 1985 Sep 16;131(2):974-9. doi: 10.1016/0006-291x(85)91335-x.

PubMed ID

3863619 [ View in PubMed

]

Abstract

The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. The comparison with similar enzyme activities from other tissues (liver, lung, serum, polymorphonuclear granulocytes) revealed a high specificity of cilastatin for the kidney enzyme which was found to be associated with the microsomal fraction. The lowest detectable inhibitory concentration of cilastatin within renal tissue was 8 X 10(-8)M.

DrugBank Data that Cites this Article

Drugs

Cilastatin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cilastatin	Dipeptidase 1	Protein	Humans	Yes	Inhibitor	Details