Potential fluoride toxicity from oral medicaments: A review.

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Ullah R, Zafar MS, Shahani N

Potential fluoride toxicity from oral medicaments: A review.

Iran J Basic Med Sci. 2017 Aug;20(8):841-848. doi: 10.22038/IJBMS.2017.9104.

PubMed ID
29085574 [ View in PubMed
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Abstract

The beneficial effects of fluoride on human oral health are well studied. There are numerous studies demonstrating that a small amount of fluoride delivered to the oral cavity decreases the prevalence of dental decay and results in stronger teeth and bones. However, ingestion of fluoride more than the recommended limit leads to toxicity and adverse effects. In order to update our understanding of fluoride and its potential toxicity, we have described the mechanisms of fluoride metabolism, toxic effects, and management of fluoride toxicity. The main aim of this review is to highlight the potential adverse effects of fluoride overdose and poorly understood toxicity. In addition, the related clinical significance of fluoride overdose and toxicity has been discussed.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Sodium fluorideHydroxyapatiteSmall moleculeHumans
Unknown
Not AvailableDetails