Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption.

Article Details

Citation
Copy to clipboard

Gupta A, Arora P, Malhotra P, Sardana K

Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption.

Dermatol Online J. 2018 Aug 23;24(6).

PubMed ID
30142724 [ View in PubMed
]
Abstract

Fixed drug eruption is a delayed type hypersensitivity reaction to a drug seen most frequently with antibiotics such as tetracyclines, sulfonamides, and NSAIDs such as naproxen and ibuprofen. Although H1-antihistamines rarely elicit cutaneous adverse effects, there have been a few reports in the literature implicating them in causing fixed drug eruption, particularly the piperazine derivatives (hydroxyzine, cetirizine, levocetirizine), and loratadine. However, cutaneous drug reactions with the alkylamine derivatives like pheniramine maleate are extremely uncommon and fixed drug eruptions have not been reported with any of the alkylamine antihistamines to date. We herein report a case of multifocal bullous fixed drug eruption following ingestion of pheniramine maleate.

DrugBank Data that Cites this Article

Drugs