The odd sibling: features of beta3-adrenoceptor pharmacology.

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Cernecka H, Sand C, Michel MC

The odd sibling: features of beta3-adrenoceptor pharmacology.

Mol Pharmacol. 2014 Nov;86(5):479-84. doi: 10.1124/mol.114.092817. Epub 2014 Jun 2.

PubMed ID
24890609 [ View in PubMed
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Abstract

beta3-Adrenoceptor agonists have recently been introduced for the treatment of overactive urinary bladder syndrome. Their target, the beta3-adrenoceptor, was discovered much later than beta1- and beta2-adrenoceptors and exhibits unique properties which make extrapolation of findings from the other two subtypes difficult and the beta3-adrenoceptor a less-understood subtype. This article discusses three aspects of beta3-adrenoceptor pharmacology. First, the ligand-recognition profile of beta3-adrenoceptors differs considerably from that of the other two subtypes, i.e., many antagonists considered as nonselective actually are beta3-sparing, including propranolol or nadolol. Many agonists and antagonists classically considered as being beta3-selective actually are not, including BRL 37,344 ((+/-)-(R*,R*)-[4-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy] acetic acid sodium hydrate) or SR 59,230 (3-(2-ethylphenoxy)-[(1S)-1,2,3,4-tetrahydronaphth-1-ylamino]-(2S)-2-propanol oxalate). Moreover, the binding pocket apparently differs between the human and rodent beta3-adrenoceptor, yielding considerable species differences in potency. Second, the expression pattern of beta3-adrenoceptors is more restricted than that of other subtypes, particularly in humans; this makes extrapolation of rodent findings to the human situation difficult, but it may result in a smaller potential for side effects. The role of beta3-adrenoceptor gene polymorphisms has insufficiently been explored and may differ even between primate species. Third, beta3-adrenoceptors lack the phosphorylation sites involved in agonist-induced desensitization of the other two subtypes. Thus, they exhibit downregulation and/or desensitization in some, but not other, cell types and tissues. When desensitization occurs, it most often is at the level of mRNA or signaling molecule expression. All three of these factors have implications for future studies to better understand the beta3-adrenoceptor as a novel pharmacological target.

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