Pharmacokinetics of nadolol in healthy subjects.

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Schafer-Korting M, Bach N, Knauf H, Mutschler E

Pharmacokinetics of nadolol in healthy subjects.

Eur J Clin Pharmacol. 1984;26(1):125-7.

PubMed ID
6714285 [ View in PubMed
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Abstract

In 7 healthy subjects (3 males and 4 females), the kinetics of nadolol was investigated after oral doses of 60 and 120 mg. The t 1/2 was 14.0 +/- 1.8 h. The peak plasma level was doubled on doubling the dose (from 69 +/- 15 to 132 +/- 27 ng/ml, respectively) and the urinary excretion (13.5%) rose similarly. The half-life of elimination was longer at night than in the day, probably because of the slower nocturnal flow of urine.

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