Ergotamine and dihydroergotamine: a review.
Article Details
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Bigal ME, Tepper SJ
Ergotamine and dihydroergotamine: a review.
Curr Pain Headache Rep. 2003 Feb;7(1):55-62.
- PubMed ID
- 12525272 [ View in PubMed]
- Abstract
The ergot alkaloids were the first specific antimigraine therapy available. However, with the advent of the triptans, their use in the treatment of migraine has declined and their role has become less clear. This review discusses the pharmacology, efficacy, and safety of the ergots. In randomized clinical trials, oral ergotamine was found to be superior to placebo, but inferior to 100 mg of oral sumatriptan. In contrast, rectal ergotamine was found to have higher efficacy (73% headache relief) than rectal sumatriptan (63% headache relief). Intranasal dihydroergotamine was found to be superior to placebo, but less effective than subcutaneous and intranasal sumatriptan. Ergotamine is still widely used in some countries for the treatment of severe migraine attacks. It is generally regarded as a safe and useful drug if prescribed for infrequent use, in the correct dose, and in the absence of contraindications; however, safer and more effective options do exist in the triptans. In patients with status migrainous and patients with frequent headache recurrence, ergotamine is still probably useful.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ergotamine 5-hydroxytryptamine receptor 1A Protein Humans UnknownAgonistDetails Ergotamine 5-hydroxytryptamine receptor 1F Protein Humans UnknownAgonistDetails Ergotamine 5-hydroxytryptamine receptor 2C Protein Humans UnknownAgonistDetails Ergotamine D(1) dopamine receptor (Protein Group) Protein group Humans UnknownAgonistDetails