Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1.
Article Details
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Murray GI, Melvin WT, Greenlee WF, Burke MD
Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1.
Annu Rev Pharmacol Toxicol. 2001;41:297-316. doi: 10.1146/annurev.pharmtox.41.1.297.
- PubMed ID
- 11264459 [ View in PubMed]
- Abstract
Cytochrome P450 CYP1B1 is a relatively recently identified member of the CYP1 gene family. The purpose of this commentary is to review the regulatory mechanisms, metabolic specificity, and tissue-specific expression of this cytochrome P450 and to highlight its unique properties. The regulation of CYP1B1 involves a variety of both transcriptional and post-transcriptional mechanisms. CYP1B1 can metabolize a range of toxic and carcinogenic chemicals in vitro but in some cases with a unique stereoselectivity. Estradiol 4-hydroxylation appears to be a characteristic reaction catalyzed by human CYP1B1. However, there are considerable species differences regarding the regulation, metabolic specificity, and tissue-specific expression of this P450. In humans CYP1B1 is overexpressed in tumor cells, and this has important implications for tumor development and progression and the development of anticancer drugs specifically activated by CYP1B1.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Estradiol acetate Cytochrome P450 1B1 Protein Humans UnknownSubstrateDetails Estradiol cypionate Cytochrome P450 1B1 Protein Humans UnknownSubstrateDetails Estradiol valerate Cytochrome P450 1B1 Protein Humans UnknownSubstrateDetails