5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture.

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Sebben M, Ansanay H, Bockaert J, Dumuis A

5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture.

Neuroreport. 1994 Dec 20;5(18):2553-7.

PubMed ID

7696602 [ View in PubMed

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Abstract

5-HT receptor positively coupled to adenylyl cyclase in striatal neurones in culture does not correspond to the 5-HT4 receptor. 5-HT induces an increase in cAMP level with an EC50 of 125 nM. 5-HT agonists displayed the following rank order of potencies 5-HT > LSD > 5-MeOT > 5-CT. 8-OH-DPAT, RU 24969 and cisapride were inactive. The most efficacious antagonists were methiothepin and tricyclic antipsychotic drugs (clozapine, amitriptyline and nortryptyline). The pharmacological profile defined by both functional studies (cAMP level) and binding experiments ([125I]-LSD binding), and its localization in striatal neurones are in favour of the presence of the recently cloned 5-HT6 receptor in these cells.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amitriptyline	5-hydroxytryptamine receptor 6	Protein	Humans	Unknown	Antagonist	Details